Bioavailability refers to the amount of a substance that is dissolved into the bloodstream to produce active effects. CBD oil typically has low bioavailability: because oil and water don’t mix, CBD molecules resist dissolution in the bloodstream, behaving much like oil in water. As a result, the majority of the dosage of CBD oil that you consume is left behind in the bloodstream and goes to waste, while only a small fraction actually circulates through the body to produce
effects. Even in large doses, then, CBD oil will produce minute effects. The potency and efficiency of any CBD product ultimately comes down to bioavailability, which is determined by the rate and efficacy with which CBD dissolves into the bloodstream–and because CBD oil cannot mix with the water in our blood, it cannot (even at large doses) produce beneficial effects.

Vana Labs’ water soluble products, on the other hand, are 90% bioavailable (nearly nine times more bioavailable than CBD oils). CBD alone cannot dissolve in water, yet this problem can be solved through the use of an emulsifier, a fatty base that acts as an intermediary between two incompatible substances (such as CBD and water). This fat-based emulsifier makes CBD and the water in the bloodstream compatible.

Meanwhile, because our CBD nanoparticles are so small, they enter the body through pathways that typical CBD particles are too large to pass through. Our CBD nanoparticles are so small that they can enter the body through cell membranes in the gut, esophagus, and mouth. The CBD  molecules in typical CBD oils, on the other hand, are too large to move through these membranes; instead, they must pass through the liver and digestive system before being absorbed by the body. This is why the bioavailability of water soluble CBD is so far superior to that of CBD oil.